Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.
Lynette balks at the idea of seeing a couples' therapist. In the meantime, Katherine is seeing her own psychiatrist, whereas Gabrielle and Susan are determined to find out which of if their kids are in the smartest math group at school, Orson makes life harder for Bree and Angie disapproves of Danny's new girlfriend.
Susan turns up the heat for Mike, Bree learns it won't be easy to undo the hurt she's caused Orson, Lynette discovers Tom's true intentions, and Gaby is forced to examine feelings she's suppressed about her heritage.
In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices.
Gabrielle and Lynette's friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny's vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.
Angie decides it's time for her and her family to leave Wisteria Lane considering another attack may occur, while Bree's affair with Karl becomes harder to keep a secret and results in Bree and Susan literally up in each other's arms. Meanwhile, a rift with Gaby is caused by Lynette's pregnancy, and the result of a confrontation between Mike and Katherine is a harmful and unexpected blow.
Susan discovers a surprising connection between her husband and Katherine Mayfair, which leads her to question her relationship with Mike. Meanwhile, Gabrielle will stop at nothing to get her daughter Juanita in Catholic school, and Lynette's pregnancy becomes impossible to hide. As Bree tries to hide her infidelity, Angie uncovers the truth about Orson and Bree's less than perfect marriage.
Susan believes Katherine maybe have been Julie's assailant, but Lynette has her own suspicions regarding who may have strangled her. In the meantime, Gabrielle struggles to homeschool her daughter Juanita. The Bolens invite the Hodges over for dinner, and Angie confronts her husband about a secret he seems to be withholding from her.
Bree begins to fall for Karl and drifts further from her husband, and Katherine continues her sad attempts at seducing Mike, as her conflict with Susan grows. After Juanita says something she shouldn't during a school play, Gabrielle erroneously gets her expelled from school, and Lynette learns her husband Tom is cheating during mid-term.
Gabrielle is deemed a bad mother during her daughter Juanita's party, and she tries desperately to prove to others that she is a responsible parent. Bree gets defensive when she's judged by a motel maid for having an affair with Karl Mayer, and Lynette is put off by her new handyman when he defers to Tom for approval on all things, whereas Susan and Katherine come to blows over Mike. Meanwhile, a lapse in judgment on Danny's part leads to a terrible mishap that Angie and Nick must cover up.
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